Network analysis reveals strain-dependent response to misfolded tau aggregates

To investigate the effect of wild-derived genetic background on modeling tau aggregation, we injected either AAV-eGFP or AAV-hTauP301L into postnatal day 0 mice to drive widespread expression. We then performed gene expression profiling analysis using data obtained from mRNA-seq from mouse brain cortex of 6 month old hTauP301L- or eGFP-mice. Comparative gene expression profiling analysis of mRNA-seq data for eGFP or hTauP301L mice on the following genetic backgrounds: C57BL6/J, CAST/EiJ, PWK/PhJ, and WSB/EiJ (n=4/background/injection/sex=64).