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Systems biology greatly improve activity of secreted therapeutic sulfatase in CHO bioprocess
Rare diseases are, despite their name, collectively common and millions of people are affected daily of conditions where treatment often is unavailable. Sulfatases are a large family of activating enz
NIAID Data Ecosystem70
Epigenetically stable integration sites
Site-specific integration into safe harbors is a strategy to overcome the problem of productivity loss over time in CHO cells. In this study, we established a CRISPR/Cas9-mediated site-specific integr
NIAID Data Ecosystem30
Ribosome profiling-guided depletion of an mRNA improves CHO cell growth and recombinant product titers
We present the first comprehensive genome-wide view of CHO translational activity during recombinant expression by the application of ribosome profiling. The distribution of translational power in CHO
NIAID Data Ecosystem70
Albumin-Based Transport of Nonsteroidal Anti-Inflammatory Drugs in Mammalian Blood Plasma
Every day, hundreds of millions of people worldwide take nonsteroidal anti-inflammatory drugs (NSAIDs), often in conjunction with multiple other medications. In the bloodstream, NSAIDs are mostly boun
Figshare2020-05-29 更新30
