Clinical significance of p53 abnormal expression in low-grade endometrial cancer

We conducted the present study to reveal the clinical significance of p53 abnormal immunohistochemical expression in low-grade endometrial cancer. Overall design: We obtained nine frozen samples of endometrial cancer (low-grade endometrial cancer with p53 wild-type expression: n=3, low-grade endometrial cancer with p53 abnormal expression: n=3, and high-grade endometrial cancer: n=3). RNA-sequencing was performed for each sample.