Cryo-EM structure of CRISPR-associated cA4 bound Cat1 Pentagonal filament assembly in the presence of NAD analog BAD

Cryo-EM structure of CRISPR-associated cA4 bound Cat1 Pentagonal filament assembly in the presence of NAD analog BAD Descriptor: Cat1 (CRISPR-associated TIR 1), RNA (5'-R(P*AP*AP*AP*A)-3'), [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl [(2R,3S,4R,5S)-5-(3-carbamoylphenyl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate (non-preferred name) Authors: Majumder, P, Patel, D.J. Deposit date: 2025-01-14 Release date: 2025-04-16 Last modified: 2025-06-25 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Cat1 forms filament networks to degrade NAD + during the type III CRISPR-Cas antiviral response. Science, 388, 2025