Rho family GTPases regulate cellular processes and promote tumour growth and metastasis; thus, RhoA is a potential target for tumour metastasis inhibition. However, limited progress has been made in t
HCT-116 cells were engrafted s.c. in nude mice. 5 to 6 days later, tumor-bearing mice were randomized to six groups and treated once with 0.5, 1 or 2 mg/kg MICAB1 PDB2G-ADCs, IC-PBD2G or vehicle. Tumo
Advanced computational tools focusing on protein–protein interaction (PPI) based drug development is a powerful platform to accelerate the therapeutic development of small lead molecules and repurpose
