Effect of resistance training combined with β-glucan ingestion on bone of ovariectomized mice

This study aimed to evaluate the effects of resistance training (RT) combined with prebiotic β-glucan (BG) ingestion (Saccharomyces cerevisiae) in ovariectomized (OVX) mice. Forty-eight mice were divided into six treatments: SHAM group and five OVX groups treated with saline (SAL), alendronate (ALE) (0.1 mg/kg), BG (62.5 mg/kg), RT (climbing a ladder with load) and the combination of BG + RT. All treatments were performed three times per week for 8 weeks starting 38 days after ovariectomy. OVX effectiveness was confirmed by a reduction in uterus mass (p p DEXA) results were higher for the SHAM and RT groups compared to the other groups (p 0.05). RT provided similar bone mass and resistance to fracture to ALE and SHAM. We found a similar number of osteocytes in the RT and SHAM groups, which was significantly higher than that found in animals receiving BG (p RT promoted benefits on bone health in the OVX model, which were not complemented by the consumption of BG.