Refillable intraocular drug-eluting implant

The increasing incidence of ophthalmic diseases has led to the need for multiple dosage regimens, which can cause patient discomfort and noncompliance due to the frequency of medication administration. Still, ophthalmic drug delivery methods, such as eye drops and intravitreal injection, pose challenges, such as poor bioavailability, short half-life, and patient compliance. In this study, we introduce a novel refillable intracapsular drug-eluting reservoir for the long-term management of ocular diseases. This device, made of medical-grade silicone and stainless steel, has features to contour the lens capsule to facilitate microincisional implantation. Rheological and mechanical analyses of the silicone revealed the optimized conditions for the device construction and its application compliance for ocular intracapsular implantation. Furthermore, in vitro release studies exhibit controlled drug release, the kinetics of which were consistent with Fickian diffusion, while ex vivo implantati..., , # Data from: Refillable intraocular drug-eluting implant

Dataset DOI: [10.5061/dryad.08kprr5h8](https://doi.org/10.5061/dryad.08kprr5h8)

## Description of the data and file structure

This provides the raw data from the manuscript

Kim, Hyeonji, et al. \"Refillable Intraocular Drug-Eluting Implant.\" *ACS Applied Materials & Interfaces* 17.23 (2025): 33474-33482

The Excel files are labeled by individual figure in the publication.

### Files and variables

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#### File: Fig_2A_raw_data.csv

**Description:** This contains data from Figure 2A showing shear rate of uncured silicone at various times.

##### Variables:

* Shear rate is in the first column, and corresponding viscosities are listed at times 0, 1, 2, and 3 hours in columns 2-5.

#### File: Fig_2B_raw_data.csv

**Description:** This contains data from Figure 2B showing complex modulus of uncured silicone at various times.

##### Variables:

* Angular frequency is in the first column, and corresponding complex modulus are list..., ,