It is becoming increasingly evident that the degradation of nuclear proteins requires nuclear-cytoplasmic trafficking of both the substrate proteins, as well as the E3 ubiquitin-ligases. Here, we show
Four different Adar knockout alleles have been studied so far. All of them show the same phenotype at E12.5, namely, apoptosis, liver disintegration and elevated immune response triggered via MDA5/MAV
Additional file 4: Table S3. List of the proteins obtained after tandem mass spectrometry analysis of immunoprecipitation of HIF1α from J774 macrophages under hypoxia.
Hypoxia-inducible transcription factors (HIFs) are fundamental to the cellular adaptation to low oxygen levels but how they interact with chromatin and efficiently activate their target genes is uncle
