Expression data of glycogenic enzymes in high glucose-induced HepG2 cells and key proteins of LKB1/AMPK pathway to explore the role of quercetin and isoquercetin in hepatic gluconeogenesis.

The aim of this study was to explore the role of quercetin and isoquercetin in hepatic gluconeogenesis, using the human liver tumor cell line HepG2. The mRNA expression of PEPCK, G6Pase, and LKB1 was evaluated using RT-qPCR. The protein expression of LKB1, TORC2, P-TORC2, AMPK, p-AMPK, SIK1, and p-SIK1 was evaluated using western blotting.