Crystal structure of the MBP-MCL1 complex with highly selective and potent Cyclic peptide inhibitor

Crystal structure of the MBP-MCL1 complex with highly selective and potent Cyclic peptide inhibitor Descriptor: Maltose/maltodextrin-binding periplasmic protein,Induced myeloid leukemia cell differentiation protein Mcl-1, TYR-LEU-LEU-PHE-TRP-ARG-ASP-GLU-LEU-ILE-LEU-LEU-CCJ-NH2, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, ... Authors: Li, F.W. Deposit date: 2024-04-30 Release date: 2025-03-19 Last modified: 2025-04-02 Method: X-RAY DIFFRACTION (2.79 Å) Cite: De novo discovery of a molecular glue-like macrocyclic peptide that induces MCL1 homodimerization. Proc.Natl.Acad.Sci.USA, 122, 2025