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Parallel Copper Catalysis: Diastereoselective Synthesis of Polyfunctionalized Azetidin-2-imines

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NIAID Data Ecosystem2026-03-07 收录
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An efficient and diastereoselective synthesis of highly functionalized azetidin-2-imines has been achieved through a parallel catalysis strategy, including a copper-catalyzed azide–alkyne cycloaddition, a copper-catalyzed Csp–Csp2 cross-coupling reaction, and an intermolecular [2 + 2] cycloaddition. The products could be conveniently converted into the structurally interesting dihydroazeto[1,2-a]benzo[e]azepin-2(4H)-imines.

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2016-02-19
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