Anaerobic O-demethylase system gene fasta files (source: JGI IMG/M metagenomic databases)

All bacterial and bathyarchaeia O-demethylase sequences retrieved using custom HMM models from metagenomic datasets as cited in the study. Files for individual datasets are provided with separate lists for CP, MT1 and MT2 (bacteria) and MtgC, MtgB and MtgA (bathy) proteins.An excel file is also provided listing all the sequence accession numbers for JGI IMG/M database and indicating if they are part of a co-localized system, where all 3 genes are found on the same contig/scaffold. All protein sequences meet the minimum sequence identity threshold = E-30 exceptions, if any, are indicated in the notes column.The datasets might also have few identical CP and MT2 sequences, indicated by red highlight entries. These sequences are found in either hit set due to similar pterin-binding sequence regions in both proteins. However, no co-localized system gene sets have identical CP and MT2 genes. Users can further curate the identical hits by looking for other conserved motifs such as corrinoid-binding region in the CP protein. This region is described in the publication. No such similarities are observed for the bathyarchaeial sequences.