Arabidopsis PDS5 genes play pivotal roles in genome organization via suppressing TAD formation

Eukaryote genomes in interphase nuclei are organized in a non-random, hierarchical fashion that correlates to gene expression and other biological activities in the nucleus. One key structural element in the three-dimensional (3D) chromatin organization is the Topologically Associating Domain (TAD), which facilitates the creation of distinct chromatin compartments and specific chromatin interactions, including those between enhancers and their target genes. Similar chromatin compartments, known as TAD-like domains, have been identified in many plant species. However, they have been curiously sparse in the model plant Arabidopsis thaliana. In our recent research, we observed substantial formation of TAD-like domains in an Arabidopsis mutant plant. This webpage contains various types of datasets supporting our conclusion. Please check "Figshare_file_description.xlsx" for details of individual files.