Organocatalytic Cascade Sulfa-Michael/Aldol Reaction of β,β‑Disubstituted Enones: Enantioselective Synthesis of Tetrahydrothiophenes with a Trifluoromethylated Quaternary Center
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https://figshare.com/articles/dataset/Organocatalytic_Cascade_Sulfa_Michael_Aldol_Reaction_of__Disubstituted_Enones_Enantioselective_Synthesis_of_Tetrahydrothiophenes_with_a_Trifluoromethylated_Quaternary_Center/2360992
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资源简介：
A bifunctional
squaramide-catalyzed sulfa-Michael/aldol cascade
reaction initiated by sulfa-Michael addition of mercaptoacetaldehyde
to β-aryl-β-trifluoromethylated enones is successfully
developed. The functionalized tetrahydrothiophenes with three continuous
stereocenters including a trifluoromethylated quaternary carbon are
readily obtained with moderate to good yields and high enantioselectivities.
创建时间：
2016-02-18
