Organocatalytic Cascade Sulfa-Michael/Aldol Reaction of β,β‑Disubstituted Enones: Enantioselective Synthesis of Tetrahydrothiophenes with a Trifluoromethylated Quaternary Center
收藏NIAID Data Ecosystem2026-03-07 收录
数据链接：
官方服务：
资源简介：
A bifunctional squaramide-catalyzed sulfa-Michael/aldol cascade reaction initiated by sulfa-Michael addition of mercaptoacetaldehyde to β-aryl-β-trifluoromethylated enones is successfully developed. The functionalized tetrahydrothiophenes with three continuous stereocenters including a trifluoromethylated quaternary carbon are readily obtained with moderate to good yields and high enantioselectivities.
创建时间：
2016-02-18
