Investigating the Structural and Functional Consequences of Pathogenic SNPs on Human VEGFA Dimer: Insights from Molecular Dynamics Study

The structures of native VEGFA, the R262Q and C266Y mutant variants, and their complexes with VEGFR1 D2 and D3 are available and associated with this manuscript. Investigating the Structural and Functional Consequences of Pathogenic SNPs on Human VEGFA Dimer: Insights from Molecular Dynamics Study Rajib Islam1,$, Md. Jahirul Islam1, Sadia Jaman1, Md. Arafat Hossen1, Sayeda Samina Ahmed1,¥ , Syeda Samira Afrose2, Md. Junaid2, Md Shahinozzaman3, and Mohammad A. Halim4* 1Division of Computer-Aided Drug Design, The Red-Green Research Centre, BICCB, 16 Tejkunipara, Tejgaon, Dhaka, 1215, Bangladesh 2Genomic and Proteomic Research Division, ABCD Laboratory, Bangladesh, Chattogram, 4226, Bangladesh 3Division of Pharmaceutical Quality Research, Office of Pharmaceutical Quality Research, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD 20993, USA 4Department of Chemistry and Biochemistry, Kennesaw State University, Kennesaw, Georgia, 30114, USA Current Address $Department of Chemistry, Clemson University, Clemson, South Carolina 29634, USA ¥Department of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton, Florida 33431, USA * Corresponding Author Mohammad A. Halim, E-mail: [e-mail]