ONFH × pan-PCD eQTL-MR — code and locked result tables

Analysis code and locked intermediate result tables for a genome-wide, multi-pathway programmed-cell-death (ferroptosis, pyroptosis, cuproptosis, disulfidoptosis) eQTL Mendelian randomization study of osteonecrosis. Outcomes from FinnGen R12 (M13_OSTEONECROSIS 2043 cases; OSTEON_DRUGS 377 cases; 3 secondary musculoskeletal endpoints). Exposures: cis-eQTL-predicted expression of 943 pan-PCD genes (FerrDb V2, Shi 2017/Broz 2020, Tsvetkov 2022, Liu 2023) from eQTLGen (n=31,684 whole blood). Bayesian colocalization for all 15 leading candidates with prior-sensitivity check, SMR consistency test, GTEx v8 multi-tissue triangulation, MR-PRESSO, GEO GSE123568 transcriptomic comparison, and a GWAS Catalog pleiotropy screen. Pre-specified discovery hierarchy prioritises colocalization and cross-phenotype consistency over FDR. Code is licensed under MIT; data tables and documentation under CC-BY-4.0.