AD-linked R47H-TREM2 mutation induces disease-enhancing microglial states via AKT hyperactivation
收藏Alliance of Genome Resources2026-08-01 收录
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We identified enrichment of a disease-enhancing, proinflammatory subpopulation of microglia in human AD patient brains with the R47H-TREM2 mutation, and uncovered that enhanced Akt signaling in microglia underlies the proinflammatory cytokine state and synaptic toxicity in our R47H-TREM2 tauopathy mouse model. Droplet-based single nuclear RNA sequencing of mouse hippocampus with and without the TREM2-R47H mutation and MK-2206 treatment.
