A-to-I RNA editing and somatic mutations have a similar magnitude of contribution to proteomic diversity in cancer

Through the proteogenomic approach, we identified several adenosine-to-inosine RNA editing sites with mass spectrometry evidence. For the enzymes, ADAR1 and ADAR2, are responsible for A-to-I RNA editing, we perturbed the expression levels of the two genes to further validate those RNA editing sites in three cell lines, including Hs578T, SLR23 and SLR25.