Single-Cell Atlas of Neuroglial Dynamics in SNCA-A53T Parkinson's Disease Model

Single-cell sequencing reveals that activation of the neuroinflammatory axis triggered by mutations in the SNCA gene A53T and dysregulation of the transcriptional regulatory network in Parkinson's disease (PD) combine to shape a cell-specific pathological picture of the substantia nigra-striatal pathway Overall design: Two samples were obtained from the midbrain tissue of A53T mice; Two samples were obtained from the midbrain tissue of wild-type mice; One sample was obtained from the striatum tissue of A53T mice; A sample is derived from the striatum tissue of wild-type mice