Crystal structure of human BCL6 BTB domain in complex with compound 12c and its enantiomer 12b

Crystal structure of human BCL6 BTB domain in complex with compound 12c and its enantiomer 12b Descriptor: (2R)-2-[[6-[(2-chloranyl-3-cyano-pyridin-4-yl)amino]-2-oxidanylidene-1H-quinolin-4-yl]amino]-N-methyl-propanamide, (2S)-2-[[6-[(2-chloranyl-3-cyano-pyridin-4-yl)amino]-2-oxidanylidene-1H-quinolin-4-yl]amino]-N-methyl-propanamide, 1,2-ETHANEDIOL, ... Authors: Collie, G.W, Le Bihan, Y.-V, van Montfort, R.L.M. Deposit date: 2021-05-17 Release date: 2021-12-08 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.43 Å) Cite: Into Deep Water: Optimizing BCL6 Inhibitors by Growing into a Solvated Pocket. J.Med.Chem., 64, 2021