Related to Fig 1B; 197 proteins that were detected by all three <i>Ripk3</i>-targeting sgRNAs but that were not detected with the non-targeting sgRNA control.
Data from the CRISPR library screen enabled us to isolate the target protein in this research. Using live-cell imaging, we were able to validate the involvement of the hits from the CRISPR library scr
data used to create main figures for: Park et. al., Efficient prioritization of CRISPR screen hits by accounting for targeting efficiency of guide RNA, BMC Biol, 2023.
The ATR kinase, which coordinates cellular responses to DNA replication stress, is also essential for the proliferation of normal unstressed cells. Although its role in the replication stress response
