Wnt signaling in kidney disease

This pathway is modeled after Figure 5 of the article "Glomerulocystic kidney disease" (Bissler, et al. 2010). The gene product Wnt signals two different paths titled canonical and non-canonical. The non-canonical path is mediated by the membrane bound protein Disheveled (Dvl) which then controls the planar cell Polarity. The canonical path on the other hand is mediated by the cytoplasmic protein Disheveled (Dvl) and then is effected through b-catenin transcription. The complex of Nphp2 and Nphp3 seem to help facilitate the process by controlling the Wnt signaling. Bergmann, et al. (2008) showed that Nphp3 deficiency in Xenopus resulted to planar cell polarity defects.

本路径模式参考自文章《肾小球囊性肾病》中的图5（Bissler等人，2010年）。基因产物Wnt信号通过两种不同的途径发挥作用，分别为经典途径和非经典途径。非经典途径由膜结合蛋白Disheveled（Dvl）介导，进而调控平面细胞极性。而经典途径则由细胞质蛋白Disheveled（Dvl）介导，并通过β-catenin转录进行调控。Nphp2和Nphp3的复合体似乎有助于促进该过程，其作用机制是通过控制Wnt信号。Bergmann等人（2008年）的研究表明，在非洲爪蟾中，Nphp3的缺乏会导致平面细胞极性缺陷。