Body weight, cortical area and lateral subchondral bone parameters in female mice.

Two-way ANOVA was used to assess the effects of surgery (control vs. surgery destabilizing the medial meniscus [DMM]) and genotype (Wnt16flox/flox vs. Cre-Wnt16flox/flox). The femoral cortical area was affected by genotype but not surgery, and no significant genotype by surgery interaction was detected. The lateral bone plate thickness was affected by surgery, but there was no effect of genotype or genotype by surgery interaction. Body weight, lateral trabecular thickness and number was not affected by surgery, genotype or genotype by surgery interaction. BV/TV bone volume/tissue volume. Data are presented as mean ± SEM, P