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Mesoscale DNA Features Impact APOBEC3A and APOBEC3B Deaminase Activity and Shape Tumor Mutational Landscapes

NIAID Data Ecosystem2026-05-01 收录

肿瘤突变机制

DNA脱氨酶功能

数据链接：

https://www.ncbi.nlm.nih.gov/bioproject/PRJNA1010353 数据链接链接失效反馈

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资源简介：

Fastq files for sequencing data obtained from Oligo-seq experiments.

应用场景：

创建时间：

2023-08-29

RNA剪接调控

肿瘤突变机制

Mutations in the splicing factor Serine Arginine Rich Splicing Factor 2 (SRSF2) occur in over 30% of patients with myelodysplasia (MDS) and a subset of patients with acute myeloid leukemia (AML) and p

NIAID Data Ecosystem60

Disruption of deoxynucleotide biosynthesis leads to RASproto-oncogene activation and perturbation of mitochondrial metabolism [DNA-seq]

肿瘤突变机制

线粒体代谢分析

Perturbation of the deoxyribonucleotide triphosphate (dNTP) pool is recognized for contributing to the mutagenic processes involved in oncogenesis. The RAS gene family encodes well characterized oncop

NIAID Data Ecosystem30

human p53 core domain mutant M133L-V203A-N239Y-N268D-R273H

蛋白质结构解析

肿瘤突变机制

human p53 core domain mutant M133L-V203A-N239Y-N268D-R273H Descriptor: CELLULAR TUMOR ANTIGEN P53, SULFATE ION, ZINC ION Authors: Joerger, A.C, Fersht, A.R. Deposit date: 2005-01-25 Release date: 2005

Protein Data Bank Japan2023-12-13 更新20

Childhood cancer mutagenesis caused by a domesticated DNA transposase

肿瘤突变机制

母细胞瘤分子生物学

Induction of somatic oncogenic mutations by the domesticated DNA transposase PGBD5 in cerebellar progenitor cells promotes medulloblastoma development. Medulloblastomas from Ptf1a-Cre/+; Ptch1fl/fl; P

NIAID Data Ecosystem50

Full-length E47K SPOP

蛋白质结构解析

肿瘤突变机制

Full-length E47K SPOP Descriptor: Speckle-type POZ protein Authors: Cuneo, M.J, Mittag, T, O'Flynn, B, Lo, Y.H. Deposit date: 2022-08-02 Release date: 2023-01-18 Last modified: 2024-11-20 Method: ELEC

Protein Data Bank Japan2024-11-20 更新30

Mesoscale DNA Features Impact APOBEC3A and APOBEC3B Deaminase Activity and Shape Tumor Mutational Landscapes

资源简介：

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