Metabolomic profile of human plasma samples from control subjects and patients with heart failure with reduced ejection fraction.

Targeted metabolomics was employed to investigate the metabolic alterations in patients with heart failure with reduced ejection fraction (HFrEF). HFrEF is a complex cardiovascular condition where the heart is unable to pump blood effectively, failing to meet the body's metabolic demands. Despite optimal medical therapy, HFrEF patients remain at high risk for adverse outcomes.

To characterize the metabolic phenotype of HFrEF, we conducted a targeted plasma metabolomics analysis on samples from a cross-sectional exploratory study within a cohort from the Montreal Heart Institute. This cohort included 132 subjects, comprising 61 HFrEF patients and 71 control subjects. A total of 71 metabolites were measured, including standard clinical markers such as glucose, total cholesterol, HDL-cholesterol, LDL-cholesterol, triglycerides, and free fatty acids. Energy-related metabolites, such as lactate, pyruvate, and intermediates of the citric acid cycle (citrate, fumarate, and malate), were also profiled. Furthermore, 53 acylcarnitines were quantified, covering short-chain (C3-C5), medium-chain (C6-C12), long-chain (C14-C18), hydroxylated, and dicarboxylic species. Detailed metadata including group labels, age, sex, and clinical variables for each sample is also provided.

The raw metabolomics dataset is available upon request.

本研究采用靶向代谢组学方法，旨在探究心力衰竭射血分数降低（HFrEF）患者的代谢改变。HFrEF是一种复杂的 cardiovascular 疾病，心脏无法有效泵血，无法满足身体的代谢需求。尽管接受最佳药物治疗，HFrEF患者仍面临较高的不良结局风险。为了表征HFrEF的代谢表型，我们对蒙特利尔心脏研究所队列中的横断面探索性研究样本进行了靶向血浆代谢组学分析。该队列包括132名受试者，其中61名为HFrEF患者，71名为对照组。共测量了71种代谢物，包括标准临床指标如葡萄糖、总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、甘油三酯和游离脂肪酸。此外，还对与能量相关的代谢物，如乳酸、丙酮酸和三羧酸循环的中间代谢物（如草酰乙酸、富马酸和苹果酸）进行了分析。同时，还量化了53种酰基肉碱，包括短链（C3-C5）、中链（C6-C12）、长链（C14-C18）、羟基化和二羧酸种类。同时，还提供了详细的元数据，包括每个样本的组标签、年龄、性别和临床变量。原始代谢组学数据集可在请求后获得。

搜集汇总

背景与挑战

背景概述

该数据集通过靶向代谢组学分析了射血分数降低的心力衰竭（HFrEF）患者与对照者的血浆样本，包含132名受试者（61名患者和71名对照）的71种代谢物测量数据，涵盖临床标志物、能量代谢物和酰基肉碱，旨在揭示HFrEF的代谢表型特征。