Enantioselective Syntheses of Furan Atropisomers by an Oxidative Central-to-Axial Chirality Conversion Strategy

For
the first time, enantiomerically enriched atropoisomeric furans
have been accessed using a central-to-axial chirality conversion strategy.
Hence, oxidation of the enantioenriched dihydrofuran precursors gave
rise to axially chiral furans with high enantiopurities accounting
from excellent conversion percentages (cp) in most cases.

首次通过中心至轴向手性转换策略成功获取了手性富集的顺反异构糠醛。因此，对富集的手性二氢糠醛前体的氧化作用产生了轴向手性糠醛，其高对映纯度得益于大多数情况下的卓越转化百分比（cp）。