Moderate Endurance Exercise increases Arrhythmia Susceptibility and modulates Cardiac Structure and Function in a Sex Dimorphic manner.

While moderate endurance exercise has been reported to improve cardiovascular health , its effects on cardiac structure and function are not fully characterized, especially with respect to sex dimorphism. We aimed to assess the effects of moderate endurance exercise on cardiac physiology in male versus female mice. C57BL/6J mice of both sexes were run on a treadmill for six weeks. ECG and echocardiography were performed every two weeks. After six weeks of exercise, mice were euthanized, and RNA sequencing was performed to determine exercise-induced transcriptional changes. and RNA sequencing was performed to determine exercise-induced transcriptional changes.