Adipose tissue-derived microRNAs as epigenetic modulators of type 2 diabetes [DPDR_RNASEQ]

Diabetes-resistant and diabetes-prone female New Zealand Obese mice were assessed based on liver fat content and early blood glucose concentrations at 10 weeks of age before the onset of T2D. Transcriptome analysis of gonadal white adipose tissue revealed genes potentially regulated by epigenetic mechanisms such as miRNAs or DNA methylation. Overall design: RNA-sequencing was performed in gonadal white adipose tissue of 15 diabetes resistant (DR) and 15 diabetes prone (DP) animals, DR animals are healthy animals and are considered as control group.