The CRAC channel Orai in an unlatched-closed conformation; K163W loss-of-function mutation; P42212 crystal form

This deposit in the Research Collaboratory for Structural Bioinformatics Protein Data Base (PDB) includes cryogenic electron microscopy data identifying the CRAC channel Orai in an unlatched-closed conformation; K163W loss-of-function mutation; P42212 crystal form. The main summary display for this entry includes information on the experimental method, protein source, macromolecules and small molecules included in the deposit, and version history and funding identification. Data is provided for download as FASTA sequence format, the Protein Data Bases own PDB format, crystallographic information file (.cif), XML, the EM map, as well as the full validation file in either PDF or XML formats. Additionally, the PDB provides embedded visualization software to display a 3D view of the protein: PDB's Mol* viewer, NGL viewer, and JSmol. PDB provides protein family and gene product annotations, additional details about the experiment parameters, a Protein Feature Viewer (in the Sequence tab) which displays all available features and alignments of known polymer instances, and a genome view which provides graphical summaries of the correspondences between PDB Entity sequences and genomes.

本数据集存储于结构生物信息学研究协同实验室（Research Collaboratory for Structural Bioinformatics）蛋白质数据库（PDB）中，包含利用低温电子显微镜技术获得的CRAC通道Orai蛋白在非激活-闭合构象下的冷冻电镜数据；K163W功能缺失突变；P42212晶体形式。本条目的主要摘要显示包括了实验方法、蛋白质来源、存储库中包含的宏分子和微小分子以及版本历史和资金来源信息。数据以FASTA序列格式、蛋白质数据库自有的PDB格式、晶体学信息文件（.cif）、XML、电子显微镜图以及PDF或XML格式的完整验证文件提供下载。此外，PDB还提供了嵌入式可视化软件以展示蛋白质的3D视图：PDB的Mol*查看器、NGL查看器和JSmol。PDB提供了蛋白质家族和基因产物注释、关于实验参数的附加细节、蛋白质特征查看器（位于序列标签页）以显示所有已知聚合物实例的特征和对齐，以及基因组视图，该视图提供了PDB实体序列与基因组之间对应关系的图形总结。