DNA methylation analysis of epigenome-edited mice
收藏NIAID Data Ecosystem2026-03-11 收录
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资源简介：
We validate three methods for the generation of epigenome-edited mice using the dCas9-SunTag and single-chain variable fragment-TET1 catalytic domain. We generate model mice for Silver-Russell syndrome, an imprinting disorder, by target-specific DNA demethylation in the H19 differentially methylated region.
创建时间：
2020-05-21
