IP-MS analysis of Legionella pneumophila SdcB for detecting noncanonical ubiquitin crosslink by Legionella transglutaminase MavC.
收藏NIAID Data Ecosystem2026-05-01 收录
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To identify the unique ubiquitin conjugation to Legionella pneumophila SdcB, we investigated the modified SdcB by IP-MS analysis. We revealed that a Legionella transglutaminase MavC has a catalytic activity to crosslink Gln residues of ubiquitin to Lys residues of SdcB, resulting in a noncanonical ubiquitin modification, and that this modification abolish the enzymatic activity of SdcB as a E3 ubiquitin ligase.
创建时间：
2024-05-02
