Genomic Characterization of Parathyroid Cancer

Here we performed genomic characterization of twenty-nine sporadic parathyroid cancers using next generation whole exome sequencing. Thirty-three novel candidate driver genes for sporadic parathyroid cancer were proposed, in addition to previously known driver genes CDC73 and MEN1.]]> All patients undergoing surgical resection for sporadic parathyroid cancer at a tertiary cancer center over a 25-year period were identified. Patients with sporadic parathyroid cancer according to World Health Organization diagnostic criteria and with available tumor tissue were included in the study. Patients with parathyroid tumors of uncertain malignancy or atypical parathyroid neoplasms were excluded.]]>