Asymmetric Copper-Catalyzed Intermolecular Aminoarylation of Styrenes: Efficient Access to Optical 2,2-Diarylethylamines

We
have developed a copper-catalyzed enantio­selective inter­molecular
amino­arylation of alkenes using a novel N-fluoro-N-alkyl­sulfon­amide as the amine reagent, which
could react with the Cu­(I) catalyst to release a related amino radical.
After addition to styrene, the generated benzylic radical could couple
with a chiral L*CuIIAr complex to achieve
enantio­selective aryl­ation. Various optical 2,2-diaryl­ethyl­amines
were efficiently synthesized from simple styrenes with high enantio­selectivity,
and these products can serve as valuable synthons toward bioactive
molecules’ synthesis.