Correlation between expression of Endo180 in tumour cells, glioma grade and the presence of intratumoral fibrillar collagen in a high-grade glioma TMA.

79 grade III and IV gliomas arrayed as a TMA were subject to immunohistochemical staining with the anti-Endo180 mAb 39.10. Intratumoral fibrillar collagen was detected using the Masson's trichrome staining method. Clinical pathological details and scoring of the individual tumors is shown in Table S2. Shown here are the statistical correlations calculated using Fisher's exact test. There was a significantly higher proportion of Endo180 positive cases in grade IV versus grade III tumors (p = 0.0005). There was no significant difference in the deposition of intratumoral collagen between grade III and grade IV tumors (p = 0.268). There was a significant association between intratumoral collagen deposition and Endo180 expression (p = 0.026).