Interaction of DAP12 and CLM7

CLM7/TREM5 is a member of the CMRF-35/immune receptor expressed by myeloid cell (IREM) multigene family of immune receptors expressed on myeloid cells. It has a basic residue in its transmembrane domain and a functional tyrosine-based motif in its short cytoplasmic tail. This structural arrangement confers CLM7 the ability to signal through two independent pathways: one through associating with activating adaptor protein DAP12 and the other through the tyrosine motif in its cytoplasmic tail (Martinez-Barriocanal & Sayos 2006).

CLM7/TREM5 为 CMRF-35/免疫受体家族成员之一，该家族免疫受体表达于髓系细胞。该蛋白在其跨膜结构域内含有一个基本氨基酸残基，并在其短细胞质尾端具有一个功能性的酪氨酸基序。这种结构布局赋予 CLM7 通过两条独立途径进行信号传导的能力：一条是通过与激活适配蛋白 DAP12 相结合，另一条则是通过其细胞质尾端的酪氨酸基序（参见 Martinez-Barriocanal & Sayos 2006）。