SMG1 expression is reduced in Parkinson’s disease (PD), Parkinson’s disease with dementia (PDD), and dementia with lewy bodies (DLB) in brain regions with known increases in p-syn expression.

Shown in A are westerns detecting SMG1 protein (α-SMG1) in the indicated cases. The control, PD, and PDD samples are from posterior cingulate cortex. Shown in B is a bar graph illustrating the differences in SMG1 expression between disease groups. Error bars are indicated on the graphs (n = 8 per group). Reductions in SMG1 expression in PD vs control and PDD vs either PD or control are statistically significant (p<0.05). Shown in C are SMG1 western results for control and DLB samples from temporal cortex. Shown in D is a bar graph quantifying the significant reduction in SMG1 expression in DLB compared to control temporal cortex.