Mutations and polymorphisms in samples genotyped under LPV/r treatment.

Samples from 237 patients under LPV/r treatment were analyzed. The last available sample from each patient was used. Mutations were divided into three groups according to: I - amino-acids that appear in at least one algorithm for LPV/r resistance (reviewed in [39]); II - other amino-acids known to be involved in resistance to PI; III - amino-acids that are not known to be involved in resistance to PI for which a statistically significant difference between subtypes was found. Amino acids that appear in all four algorithms are shown in bold type and those that appear in 3 different algorithms in italics. For mutation that are significantly different between subtypes the most prevalent variant is shown in bold type. In order to emphasize significant differences only p values smaller than 0.1 were noted. Mutations V32I, E34Q (Group I) and E35G (Group II) did not appear at all and were taken out from the table.B – subtype B; C – subtype C; LPV/r – Lopinavir/ritonavir; non-BC– subtypes other than B or C; PI – protease Inhibitor.