Transcriptome analysis of the mandibles from FcgRIIB-deficient mouse model of lupus

To identify the extensive complexity of transcriptome in Fc gamma receptor IIB knockout (FcgRIIB−/−) mandibles. We performed gene expression profiling of mandibular bone from wild-type (WT) and FcgRIIB−/− mice at 6 months of age. Our study reports the first transcriptomic analysis in mandibles of FcgRIIB-deficient mice using RNA-sequencing (RNA-seq). The data were validated by qPCR analysis. qPCR analysis revealed similar results compared to RNA-seq data. This finding disclosed the relevant differentially expressed genes (DEGs) and clarify the mechanism underlying the pathogenesis of osteopenia. We provide novel candidate genes and enriched pathways that contribute to mandibular bone loss in FcgRIIB−/− mice during lupus development. Sufu and Serpina12 were identified as candidate molecular targets regulating osteoclastogenesis and osteogenesis, respectively. Mandibular transcriptional profiles of 6-month-old WT controls and FcgRIIB−/− male mice