File S1 - Submicron-Bubble-Enhanced Focused Ultrasound for Blood–Brain Barrier Disruption and Improved CNS Drug Delivery

File includes Method S1, Table S1, and Figures S1-S5. Table S1: Transducer characteristics and operating frequency ranges. Figure S1: The size distribution of submicron bubble measured by (A) Coulter counter and (B) dynamic light scattering at 4°C or 37°C at different time point (post bubble preparation 0 min, 30 min, 1 h, 2 h and 4 h). Figure S2: The concentration of submicron bubble measured by Coulter counter and at 4°C or 37°C at different time point (post bubble preparation 0 min, 30 min, 1 h, 2 h and 4 h). Figure S3: The experimental setup for measuring the acoustic attenuation of the submicron bubbles. Figure S4: The Attenuation measurement results of submicron bubbles. Figure S5: The acoustic pressure maps of (A) 10-MHz, (B) 5-MHz and (C) 1-MHz transducers, respectively. (DOCX)