ChIP-seq and R-ChIP-seq following BET bromodomain protein loss in HeLa cells
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE141763
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We report that treatment of HeLa cells with 2 hours of 100nM dBET6, which degrades BET bromodomain proteins, leads to global increases of RNA:DNA hybrids (R-loops) and DNA damage (γH2AX). R-loop occupancy was determined using a mutant version of RNase H1 (D210N) which binds to, but cannot resolve, R-loops. Examination of γH2AX and R-loop levels following BET bromodomain protein loss in HeLa cells
创建时间：
2020-10-02
