Data from: Curcumin is comparable to metformin for the treatment of PCOS in rats: a preclinical study. Weights and biochemical data

Background: Ploy cystic ovary syndrome (PCOS) is a common gynecological
disorder affecting between 4-20% of females worldwide. Curcumin, the
active ingredient in turmeric (Curcuma longa Zingiberaceae) is a yellow
polyphenol with a wide range of pharmacological activities such as
antioxidant, anti-inflammatory, anti-tumor, neuroprotective and
cardioprotective properties.  Methods: Letrozole was used to
induce PCOS in female Wistar rats. Curcumin, metformin, or a combination
of both was given to assess their therapeutic effects. Body weight,
estrogen, progesterone, testosterone, and glucose levels were measured
after disease induction and at the conclusion of treatment. Additionally
ovarian histomorphology was examined after sacrificing the animals and
removal of the ovaries. Results and conclusion: Weight was significantly
reduced in the curcumin, metformin and curcumin and metformin combination
groups. Testosterone was decreased, progesterone was increased, and normal
ovarian morphology was restored in the three groups. In Conclusions
curcumin is therapeutically effective for PCOS and is comparable to
metformin.