Additional file 1 of Gut microbiome transitions across generations in different ethnicities in an urban setting—the HELIUS study

Additional file 1: Table S1. Parameter grid used for tuning of the XGBoost model. Table S2.Prevotella, Bacteroides and Phocaeicola ASVs based on BLAST search. Note that Phocaeicola is included as it was previously categorized as Bacteroides. Table S3. Identification of the core ASVs in the CMO trophic network. The names for the ASVs were based on a BLAST search. Table S4. Identification of the core ASVs in the Prevotella cluster. The names for the ASVs were based on a BLAST search. Table S5. Identification of the core ASVs in the BBB cluster. The names for the ASVs were based on a BLAST search. Table S6. Clustering of ASV sequences based on phylogeny at a height of 0.1. Table S7. Summary of demographics of HELIUS subjects included in study. Table S8. Most discriminative ASVs found in machine learning that distinguish the 1st from the 2nd generation per ethnicity including the Dutch with the ranking of the importance (A), an age-only model with the overlap to the ethnicities (B) and the train-, cross-validation-, and test ROC-AUC scores with standard deviation for each model (C). Table S9. ASVs that were presented in the heatmap of the Turkish ethnicity (Fig. 5; Fig. S9). The ASV names were based on a BLAST search.