Exploring the role of extracellular vesicles in obesity and diabetes-associated cardiovascular disease

Cardiovascular diseases are a global health issue with obesity and type 2 diabetes both risk factors for the development of heart disease. Exercise is a well-known therapy for the management of complications associated with cardiovascular diseases. One approach exercise helps to aid in protection is through promoting the release of small biological particles called extracellular vesicles. These carry molecules like proteins, lipids and DNA and are released by various organs throughout the body. This thesis investigates the relationship between exercise and extracellular vesicles and highlights the ability of exercise to protect against cardiovascular diseases in settings of obesity and diabetes.