Acyl-enzyme complex of cephalothin bound to deacylation mutant KPC-2 (E166Q)
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Acyl-enzyme complex of cephalothin bound to deacylation mutant KPC-2 (E166Q) Descriptor: 5-METHYLENE-2-[2-OXO-1-(2-THIOPHEN-2-YL-ACETYLAMINO)-ETHYL]-5,6-DIHYDRO-2H-[1,3]THIAZINE-4-CARBOXYLIC ACID, Carbapenem-hydrolyzing beta-lactamase KPC, GLYCEROL, ... Authors: Tooke, C.L, Hinchliffe, P, Spencer, J. Deposit date: 2022-07-29 Release date: 2023-03-08 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (1.35 Å) Cite: Tautomer-Specific Deacylation and Omega-Loop Flexibility Explain the Carbapenem-Hydrolyzing Broad-Spectrum Activity of the KPC-2 beta-Lactamase. J.Am.Chem.Soc., 145, 2023
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2022-07-29
