Exosomal lncRNA SNHG10 derived from colorectal cancer suppress natural killer cell cytotoxicity by up-regulating INHBC

Exosomal lncRNA SNHG10 overexpressing (oe-lnc-SNHG10 exo) significantly inhibited viability and cytotoxicity of NK cells. Transcriptome sequencing of NK cells identified 114 differentially expressed genes were up-regulated in oe-lnc-SNHG10 exo group, including INHBC, which involved in TGF-beta signaling pathway. The oe-lnc-SNHG10 exo increased the tumor growth and the expression of INHBC in mice, while decreased the expression of perforin, granzyme B, and NK1.1 in tumor tissues. We demonstrate that CRC cell-derived exosomal lncRNA SNHG10 suppresses the function of NK cell by up-regulating expression of INHBC and activating TGF-beta signaling pathway. Our study provides evidence for lncRNA contributes to immune escape by inducing NK cells inhibition, and proposes a potential treatment strategies for metastatic CRC.