Thiele2013 - Lung macrophages

Thiele2013 - Lung macrophages

The model of lung macrophages metabolism is derived from the community-driven global reconstruction of human metabolism (version 2.02, MODEL1109130000
).

This model is described in the article:

A community-driven global reconstruction of human metabolism.

Thiele I, et al
.
Nature Biotechnology
Abstract:

Multiple models of human metabolism have been reconstructed, but each represents only a subset of our knowledge. Here we describe Recon 2, a community-driven,
consensus 'metabolic reconstruction', which is the most comprehensive representation of human metabolism that is applicable to computational modeling. Compared
with its predecessors, the reconstruction has improved topological and functional features, including ~2x more reactions and ~1.7x more unique metabolites. Using
Recon 2 we predicted changes in metabolite biomarkers for 49 inborn errors of metabolism with 77% accuracy when compared to experimental data. Mapping metabolomic
data and drug information onto Recon 2 demonstrates its potential for integrating and analyzing diverse data types. Using protein expression data, we automatically
generated a compendium of 65 cell type-specific models, providing a basis for manual curation or investigation of cell-specific metabolic properties. Recon 2 will
facilitate many future biomedical studies and is freely available at http://humanmetabolism.org/.

This model is hosted on BioModels Database
and identified by: MODEL1310110051
.
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curated and annotated resource for published quantitative kinetic models
.

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