Zebrafish larvae treated with triptolide (5 dpf larvae after exposure to triptolide (1.6μM) for 6 hours) or vehicle control. A total of 16 sequencing experiments were performed (control N=8 and treatm
ObjectiveTo investigate the pharmacodynamic material basis, multi-target mechanisms of Chelidonii Herba in treating chronic obstructive pulmonary disease (COPD), and its hepatotoxicity pathways using
Human liver organoids, an in vitro 3D culture system to recapitulate biological tissue, are expected to be used for drug discovery. However, Matrigel, the most widely used extracellular matrix for org