R script used for the analysis of Clinical Trial (CT) distribution worldwide associated with the Hepatitis B Virus.

Search strategy and selection criteria We searched the International CT Registry Platform (ICTRP) from the WHO, and ‘ClinicalTrials.gov’ registries for Hepatitis B Virus Clinical Trials (CT) reported in English, without limitation by start year. CT were only eligible for inclusion when focused on the pathogen of interest, but we included studies both of individuals with the relevant infection and of healthy volunteers (e.g., for HBV studies, we permitted ‘CHB’, ‘HBV’, ‘Hepatitis B’ and ’healthy’, with the latter reflecting enrolment for phase I CT for evaluation of HBV-specific interventions). Studies categorized as ‘observational’ (i.e., no intervention) or with missing location data were excluded. CTs were then sorted by WHO region, based on their registered location(s), using this R script (Version 4.2.1). Final database are published here: https://doi.org/10.6084/m9.figshare.23667480.v1