Epigenetic silencing of HAND2 is a crucial step in endometrial carcinogenesis. Homo sapiens

Here we demonstrate that epigenetic silencing of HAND2 is a key step in endometrial carcinogenesis. We performed an epigenome-wide methylation analysis of >27,000 CpG sites in endometrial cancers and controls and identified methylation of HAND2 as one of the most common hypermethylated and silenced genes in endometrial cancer. Overall design: Bisulphite converted DNA from the 87 samples were hybridised to the Illumina Infinium 27k Human Methylation Beadchip v1.2.